Laryngeal Cancer (Laryngeal Carcinoma) Platinum Package

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The Platinum Package offers in-depth molecular analysis that enables the development of highly precise and individual therapy options. Using the latest technologies such as NGS and IHC, a comprehensive picture of the genetic changes is created. In addition, in-vitro tests are carried out to determine the response to various treatments. This allows therapies to be tailored specifically and effectively to achieve optimal results.

1. Molecular profiles and genetic tests

NGS (Next Generation Sequencing) :

PIK3CA : Mutations in the PIK3CA gene enable the use of mTOR inhibitors such as everolimus. The detection of this mutation supports targeted therapy planning.
TP53 : TP53 mutations play a crucial role in tumor aggressiveness and are used to tailor therapy planning to individual patients.
TMB (tumor mutation burden) : An increased tumor mutation burden suggests that immunotherapies such as pembrolizumab or nivolumab may be effective. NGS tests determine the TMB to evaluate suitability for immunotherapies.

IHC (immunohistochemistry) :

PD-L1 : The PD-L1 status is used to determine whether the tumor responds to immunotherapies such as pembrolizumab. This analysis supports targeted therapy selection.

2. Radiotherapy :

Testing the radiation dose to ensure targeted and gentle treatment. The clonogenic assay is used to evaluate cell survival and DNA damage to determine the optimal radiation dose.

3. Drugs that can be tested in vitro

Chemotherapy :

Cisplatin, Carboplatin, 5-Fluorouracil : These chemotherapeutic agents are tested in vitro to evaluate their effectiveness on tumor cells and to determine a tailored chemotherapy regimen for the patient.

Targeted therapy :

Everolimus : This drug is used for PIK3CA mutations and is tested in vitro to evaluate the effect on tumor cells.

4. Molecular tests for systemic drugs not testable in vitro :

Pembrolizumab, Nivolumab : These immunotherapies are used in PD-L1 positive tumors. PD-L1 status is determined by IHC , while TMB level is tested by NGS to determine suitability for immunotherapy.
Bevacizumab (off-label) : Bevacizumab can be used to inhibit angiogenesis. Angiogenesis inhibition is tested by the Endothelial Cell Tube Formation Assay .

Procedure

Immediately after ordering, you will receive detailed instructions from us by email and a few days later by post, so that you can discuss them with your doctor or treating hospital. We are happy to support you with this. Feel safe and supported every step of the way!

If enough cancer cells have already been taken, the analysis can begin immediately. If additional samples are required, your doctor will discuss this with you. This will create the best conditions for an accurate analysis!

Our medical scientists and experienced pathologists precisely analyze and test your cancer cells. Depending on the package, you will receive the well-founded and decisive results for targeted cancer therapy within 1 to 3 weeks!

We have no influence on companies with whom we do not have a partnership. Therefore, we cannot influence the cost of additional cancer cell sampling, nor the speed, expertise or implementation of these measures. For this reason, we rely on your active cooperation or the support of a close person to ensure that the processes at your doctor's office run smoothly until the samples are collected.

Money-back guarantee

Your satisfaction and well-being are our top priority. If it is not possible to carry out a tissue sample for medical or organizational reasons, or if you find that you need a different package, we offer you a money-back guarantee and the option to change your package easily.

Conditions for refund:

Full reimbursement will be made if tissue sampling cannot be performed for medical reasons.
If the collection is not possible for organizational reasons on our part, you will also receive a full refund.
The refund applies to all costs directly related to the tissue collection and related services in the selected package.

Package change option:

If, after booking, you find that another package is a better fit for your diagnosis or situation – for example, if you have a very similar type of cancer – you can easily change your chosen package.
The difference will either be refunded or paid later, depending on the price difference between the packages.
A package change can be made at any time before the start of tests or treatments.

Refund and package change process:

If you would like a refund or package exchange, please contact our customer service team.
After reviewing your request, the refund or exchange will be processed within 14 working days.
The refund will be made using the same payment method you used for the original payment. If you change packages, the new price will be adjusted accordingly.

We want to make sure that you get exactly the services you need. That's why we offer you complete flexibility and security when choosing our packages. Your health and satisfaction are our top priority.

Medical note

If the progression of the cancer and urgent medical advice indicate that immediate treatment is necessary, we recommend that you start therapy. Once our results are available, treatment can be adjusted accordingly.

Maximum expansion

In addition to this package of genetic analyses and in vitro tests for approved drugs, we can also analyze other genes or test additional drugs that are of interest for the specific case, upon agreement.

Advanced genetic analyses:
Upon request and after consultation, we can specifically include additional genes or genetic markers in the analysis in order to obtain a more comprehensive molecular picture of the tumor. This enables even more precise adaptation of the treatment options to the individual genetic characteristics of the tumor.

Additional drug tests:
If there are specific cancer drugs of interest that are not part of this package, we can, by agreement, include additional drugs in the in vitro testing. This offers the opportunity to test alternative or complementary therapies that may be specifically relevant for the patient.

To use:

Maximum individualization of treatment through targeted expansion of genetic analysis.
Additional treatment options through testing of other approved medications.
Greater flexibility in adapting the treatment plan to complex or rare cancers.

Process:
If you would like additional analyses or drug tests, we will discuss the options with your treating physician. After a careful evaluation, we can integrate the desired genes or drugs into the testing process. This ensures that you receive the most comprehensive and precise information for the treatment decision.

Please contact us if you have any special requests or requirements. Together we will find the best solution to optimally support your treatment.

The offer is aimed at patients with particularly complex cases or rare cancers where additional genetic markers or alternative medications may be of interest.