3D tumor model

The 3D tumor model represents a state-of-the-art method in which patient-specific tumor cells are cultivated in a three-dimensional structure to replicate the natural tumor architecture and environment as accurately as possible. This makes it possible to test various approved cancer drugs directly on these models, leading to a realistic prediction of the drugs' effectiveness. The method overcomes the limitations of conventional 2D cell cultures by taking into account the interaction of tumor cells with their environment, thus enabling a more accurate depiction of the tumor response.

Procedures used in the 3D tumor model package:

3D cell culture technology (spheroids and organoids) :
In 3D cell culture, tumor cells from the patient are used to form spheroids or organoids that mimic the complex three-dimensional structure of a tumor. These models are particularly valuable because they closely replicate the natural growth pattern and cell-cell interactions in tumor tissue.

• • Spheroids : Spherical cell aggregates that mimic the tumor microenvironment and more realistically simulate drug response.
  • Organoids : Miniaturized and simpler versions of organs composed of the patient's tumor cells and grown in vitro. They are a more advanced form of tumor replication that allows the behavior of the tumor to be studied in a nearly natural state.

3D bioprinting :
A groundbreaking technique that uses 3D printing to print tumor cells into a matrix to recreate the complex structure of tumor tissue. This method allows for precise layered tumor structures to be created that take into account important aspects such as vascularization and microenvironment. This leads to a detailed mapping of tumor architecture and an accurate prediction of drug effects.

• • Advantage : The exact replication of the tumor structure makes it possible to realistically simulate the diffusion of drugs through the tumor tissue.

Microfluidic platforms :
These technologies simulate the microcirculation in tumor tissue by recreating nutrient flows and drug distribution in the 3D models. By integrating microfluidics, it is possible to study how the drug diffuses through the tumor environment and what effects on tumor growth can be observed in real time.

• • Advantage : Provides a dynamic analysis of drug effects that is closer to the conditions in the human body.

Automated high-throughput testing :
Automated systems are used to test the effects of a variety of drugs simultaneously on the 3D tumor models. This enables rapid identification of drugs or combinations that have the greatest effect on the patient's specific tumor model.

Services:

• Creation of a patient-specific 3D tumor model : Using the patient's tumor cells to reconstruct the tumor tissue three-dimensionally in the laboratory.
• Testing of approved drugs : In vitro testing of the effectiveness of various approved cancer drugs and combinations to evaluate the individual tumor response to the drugs.
• Simulation of the tumor environment : The 3D models simulate the complex cell-cell interactions, the microenvironment and the tumor architecture, making the testing realistic.
• Personalized recommendations : Based on the test results, precise therapy recommendations for the most effective medications are made.

To use:

• Realistic prediction of drug effects : Compared to conventional 2D cell cultures, the 3D models offer a significantly more accurate simulation of tumor reactions, leading to a better prediction of the effectiveness of cancer drugs.
• Personalized therapy planning : Testing on patient-specific models enables targeted therapy that is individually tailored to the tumor, thereby increasing the likelihood of treatment success.
• Minimizing side effects : Accurate testing in advance can exclude drugs that are ineffective or cause potentially serious side effects, making treatment safer.

A notice:
The 3D tumor model package can only be booked in conjunction with one of our cancer packages.